Endocrine Abstracts

Adrenocortical Cancer (ACC) is characterized by an increased production of insulin-like growth factor 2 (IGF2) and by estrogen receptor (ER) α up-regulation. Aim of this study was to define IGF2 and estrogen signaling interactions in ACC, in order to give new indications for a better therapy. To this aim we used H295R cells and human ACC tissues which display common features: IGF2 activation of downstream effector pathways and over-expression of estrogen-related genes inc...

Background: Actually mitotane is an adrenal-specific agent employed in the treatment of adrenocortical carcinoma (ACC), and although it has been used for several decades, its exact mechanism of action, remain to be fully elucidated. Some authors reported that mitotane affected in vitro the multidrug resistance gene mdr-1/P-glycoprotein. MRP1, belonging a multidrug resistance protein family, exerts a chemo-resistance activity in many type of cancer leading to the failure...